You WILL end up having to move mods around in both window panes for optimal optimization and game stability! One should make judicous use of Mod Organizer 2*'s conflict notification system (the left window pane) to aid in conflict resolution. Merging/fixing conflicting mods is mandatory for a stable game! Expect to spend at least half that for a semi-stable game using the following mods. To get this relatively stable has cost me roughly SEVEN DAYS of my life merging mods and solving conflicts in FO4Edit. Perk Points Per Level adjusts perkiness so that one can craft better gear.

Also using worldwide NPC > Player scaling mod so all enemies are around the players level at all times like in previous games, bosses and other harder enemies have a slightly higher multiplier than other easier enemies that have slightly lower multiplier than player level. Currently about 80 hours into the game, level 20 using no XP for kills (seriously Beth, rewarding players for killing?) and lower XP globally.

Fallout 4 super mutant companion mod